St. Louis, MO
GLP-1 Weight Loss in St. Louis, MO | Local, Responsive Medical Care Delivered Online
As St. Louisans ourselves, we understand how frustrating it can be to find weight-loss care that is both medically sound and easy to access. Many people have already tried diets, gyms, apps, or brief medical visits without the ongoing guidance needed to manage medication, side effects, plateaus, and long-term progress.
Medically supervised GLP-1 care: physician oversight and an experienced healthcare team
Monthly clinical review included: treatment adjusted to how you're responding
Licensed in Missouri: routine care is completed online, with no clinic visits
No payment required | Eligibility check takes 2-5 minutes | HIPAA-compliant systems
LegitScript Certified
Verified telehealth provider
Praxiom Health is a St. Louis-based, locally owned and operated telehealth medical practice. We combine medically supervised GLP-1 treatment, including semaglutide and tirzepatide when appropriate, with monthly clinical review and responsive access to an experienced healthcare team.
We serve patients throughout the Greater St. Louis area, including St. Louis City and County, St. Charles County, St. Peters, O'Fallon, and nearby communities. Routine care is completed online, without commuting to a clinic or arranging a video visit in the middle of your day.
This is not a prescription-and-goodbye service. It is flexible, ongoing weight-loss care with a clinical team that helps you start, manage refills, address side effects, work through plateaus, and adjust treatment as your needs change.
Serving the Greater St. Louis area
Clayton, Ladue, South City, Chesterfield, Kirkwood, Webster Groves, and nearby communities
230 South Bemiston Suite 1000, St. Louis, MO 63105
Local physician leadership
Praxiom's GLP-1 program is led by Kirk O'Donnell, MD, a lifelong St. Louisan and Mayo Clinic-trained family physician who has helped care for more than 20,000 GLP-1 weight-loss patients. Dr. O'Donnell is a U.S. Air Force flight surgeon and lieutenant colonel and serves as High Performance Medical Director for Team USA Boxing. He leads the program alongside Praxiom's physician and nursing team.
Meet the Praxiom teamWhat is GLP-1 weight-loss treatment?
GLP-1 stands for glucagon-like peptide-1, a hormone involved in blood-sugar regulation, appetite, digestion, and feelings of fullness. GLP-1 receptor agonist medications strengthen these signals, which can help patients feel satisfied with less food and reduce persistent hunger, food noise, and cravings.
Semaglutide and tirzepatide are among the most extensively studied medications used for chronic weight management. In large trials of FDA-approved products used with lifestyle intervention, participants achieved substantial average weight loss over 68 to 72 weeks. Results vary by medication, dose, duration, adherence, and individual response.
Why GLP-1 medications can help when diets alone have not
Weight struggles are not simply a lack of willpower. Biology, hormones, sleep, stress, medications, and life circumstances can all influence hunger and weight. GLP-1-based treatment can support blood-sugar regulation and reduce hunger signals, helping make it physically and mentally easier to follow the healthy choices you already know how to make.
For people who have spent years cycling through restrictive diets, this can be a meaningful shift. Medication is not a substitute for nutrition, activity, sleep, or behavior change. It can make those efforts more sustainable by reducing the biological and psychological pressure that often works against them.
Semaglutide vs. tirzepatide: what is the difference?
Semaglutide acts primarily at the GLP-1 receptor. Tirzepatide acts at both the GLP-1 and GIP receptors and has shown substantial dose-dependent weight loss in clinical trials. Both are generally administered once weekly. The best option depends on medical history, prior treatment, goals, preferences, access, cost, and response.
Your healthcare team will work with you, with physician oversight, to choose the most appropriate medication and starting dose. Treatment can be adjusted as your response, tolerability, goals, coverage, or preferences change.
The Praxiom approach: accessible expertise and ongoing support
Telehealth weight-loss programs range from quick prescription services with limited follow-up to visit-heavy programs that can be expensive and difficult to fit into daily life.
Praxiom was designed to offer a practical middle path: medically supervised care that is convenient and flexible, with a responsive healthcare team available when questions, side effects, refill needs, or plateaus arise.
An experienced healthcare team, not a rotating roster
Your care is supported by a consistent team that includes licensed nurses and physicians experienced in GLP-1 treatment. A clinician reviews your intake, the physician team provides medical oversight, and the team stays engaged as your treatment evolves. Care is not reduced to an algorithm, a generic handout, or a one-time prescription.
Monthly touchpoints, with access between reviews
Patients receive monthly clinical touchpoints and can contact the team between reviews. If progress slows, side effects emerge, life circumstances change, or you simply have a question, the healthcare team is available to provide practical guidance and make clinically appropriate changes.
Clear, individualized dosing
GLP-1 medications begin at an appropriate starting dose. Dose changes are generally considered at monthly intervals, based on response, tolerability, goals, and patient preference. The team explains what is changing and why, and a dose is never increased automatically when holding or reducing it would be safer or more appropriate.
Flexible support without mandatory appointments
Routine care is designed to be completed asynchronously, without requiring routine office or video visits. The clinical team, including licensed nurses, is accessible through the secure portal for questions and concerns outside your monthly touchpoints. Phone or video follow-up can be arranged when clinically appropriate.
Who may be a good fit for Praxiom Health?
Our program serves adults across the Greater St. Louis area who want medically supervised weight-loss care and reliable access to an experienced healthcare team.
You may be a strong candidate if:
You have overweight or obesity and a licensed clinician determines GLP-1 treatment is medically appropriate
You have tried nutrition, exercise, or other weight-management approaches without achieving durable results
You want guidance from an accessible healthcare team rather than navigating medication, dosing, side effects, and refills alone
You have used a GLP-1 medication before and had a neutral or difficult experience because support was limited
You are already using maintenance treatment and want more consistent clinical oversight and support
You are ready to participate in monthly clinical reviews and work with the team on a treatment plan that reflects your goals and preferences
Care for men and women, personalized to the individual
Weight management can be affected by hormones, metabolism, health conditions, medications, sleep, stress, nutrition, activity, and life stage. Praxiom considers those factors without forcing patients into a one-size-fits-all approach.
For women, treatment may take into account perimenopause, menopause, PCOS, endometriosis, thyroid or metabolic concerns, autoimmune conditions, and other factors that can intersect with weight and medication response.
For men, care may include attention to energy, metabolic health, cardiovascular risk factors, body composition, performance goals, nutrition, exercise, supplementation, and sustainable habits.
For every patient, dosing and support are individualized according to clinical response, tolerability, goals, and preferences.
Important limitations
Praxiom is not an emergency medical provider, and GLP-1-based treatment is not appropriate for everyone. A personal or family history of medullary thyroid carcinoma or MEN2, pregnancy, certain medication combinations, and other clinical factors may make treatment inappropriate. The intake and clinical review are used to determine whether treatment is medically appropriate and safe.
How the program works, start to finish
Praxiom is designed to make medically supervised weight-loss care easier to start and easier to continue. The current workflow is outlined below.
Step 1
Check eligibility and complete your online intake
Start with a brief eligibility screen, which takes about 2 to 5 minutes. If eligible, complete your health history, goals, and treatment questionnaire in the secure patient portal. The full intake generally takes another 5 to 10 minutes. No payment is required to begin.
Step 2
Connect with the care team
A member of the Praxiom care team contacts you to answer questions, explain available treatment paths and pricing, and help you complete any remaining steps. This keeps the process personal and ensures you understand the options before a prescription or charge.
Step 3
Clinical review and treatment selection
After the care-team review, a Praxiom physician evaluates your intake, confirms whether treatment is medically appropriate, and determines the medication and starting dose with your goals and preferences in mind. If questions or safety concerns arise, the team follows up before proceeding.
Step 4
Get your medication
If compounded medication is prescribed and available in your state, the prescription is sent to a trusted state-licensed compounding pharmacy and the medication is shipped to your home. If a brand-name medication is prescribed, it is sent to the appropriate retail or manufacturer-affiliated pharmacy and is filled and paid for separately. Delivery and pickup timing vary.
Step 5
Monthly reviews and treatment adjustments
Your healthcare team reviews your progress each month. Dose and treatment decisions are based on weight trend, appetite response, side effects, goals, adherence, and your preferences, as long as the requested approach remains medically safe and appropriate. Nothing is set and forgotten.
Step 6
Get support between monthly touchpoints
Between reviews, the team is available through the secure portal for questions, refill needs, side effects, and practical troubleshooting. When a phone or video conversation is clinically appropriate, the team can arrange it. You do not have to wait for a future visit to ask for help.
Want the full detail? See what to expect, month by month.
Frequently asked questions: Greater St. Louis patients
Is Praxiom Health licensed to serve patients in St. Louis and Missouri?
Yes. Praxiom Health is licensed to provide telehealth care in Missouri and currently serves patients in 45 states plus Washington, D.C., with availability varying by state. In the Greater St. Louis area, service includes communities such as Clayton, Ladue, South City, Chesterfield, Kirkwood, Webster Groves, Ballwin, Creve Coeur, Florissant, St. Charles, St. Peters, O'Fallon, along with nearby areas where Praxiom is licensed.
See all states we serveDo I need to come into an office?
No. Praxiom is a fully online telehealth practice. Eligibility screening, intake, clinical review, monthly follow-up, and routine support are completed remotely. Phone or video follow-up may be used when clinically appropriate, but routine care does not require a physical office visit.
How much does the program cost?
Current starting prices are $214.99 per month for compounded semaglutide packages and $263.99 per month for compounded tirzepatide packages, where available. Those packages include monthly clinical oversight, medication if prescribed, pharmacy coordination, and shipping. Pricing varies by medication and dose. Brand-name care is available for $74.99 per month, with the medication filled and paid for separately. Patients see the recommended option and price before a charge is made.
See full pricingDoes insurance cover GLP-1 medications through Praxiom?
Praxiom can prescribe FDA-approved brand-name GLP-1 medications when clinically appropriate and can submit a prior authorization when needed. Ongoing clinical oversight and prescription support for a brand-name medication are currently $74.99 per month. The medication is filled and paid for separately through the patient's pharmacy or manufacturer. A prior-authorization submission currently carries a one-time $74.99 fee. Coverage and out-of-pocket cost depend on the patient's plan. HSA or FSA documentation may be available upon request.
See brand-name pricingWhat if the medication causes side effects?
Common side effects include nausea, diarrhea, vomiting, constipation, abdominal discomfort, and sometimes fatigue, especially during dose escalation. The team helps patients prevent and manage side effects with practical nutrition, hydration, dosing, and symptom guidance. Treatment can be held, slowed, reduced, or otherwise adjusted when clinically appropriate.
How quickly will I see results?
Some patients notice changes in hunger, fullness, or food noise during the first few weeks, while weight change usually builds over time. Results vary substantially by medication, dose, duration, adherence, health conditions, and individual response. Praxiom does not guarantee a specific amount or timeline of weight loss.
Can men use GLP-1 medications for weight loss?
Yes. GLP-1-based medications are used in eligible adults of all genders. Praxiom individualizes care for men whose goals may include weight loss, energy, metabolic health, cardiovascular risk factors, body composition, or physical performance, while keeping expectations medically realistic.
See the men's programAre compounded semaglutide and tirzepatide FDA-approved?
No. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or quality before marketing. When clinically appropriate and legally available, Praxiom works with state-licensed U.S. compounding pharmacies. Compounded options should not be represented as equivalent to FDA-approved brand-name products.
Is Praxiom Health a legitimate medical practice?
Yes. Praxiom Health is a legitimate telehealth medical practice and is LegitScript certified. Care is provided by licensed clinicians, supported by HIPAA-compliant systems, and delivered according to applicable federal and state telehealth requirements. The clinical team includes physicians and licensed nursing staff experienced in GLP-1 care.
Meet the Praxiom team
Why Greater St. Louis residents choose Praxiom
People in the Greater St. Louis area have many weight-loss options. What can be harder to find is a model that combines medical oversight, flexible online care, transparent pricing, and responsive access to an experienced healthcare team.
That is the gap Praxiom is designed to fill.
Praxiom is locally based and built around individual patients, not a one-size-fits-all model. The team stays engaged month after month, helping patients manage treatment, side effects, refills, plateaus, and changing goals without adding unnecessary office or video appointments.
For Greater St. Louis patients, that means:
No routine drive to a clinic or waiting room
No mandatory video appointment in the middle of a workday for routine monthly care
Monthly clinical review plus responsive access to a healthcare team that knows your history
Treatment adjustments based on response, tolerability, goals, and patient preference
Compounded medication shipped to your home when available, or brand-name prescriptions sent to the appropriate pharmacy
If you live in the Greater St. Louis area and want flexible, medically supervised GLP-1 care with real support behind it, Praxiom is ready to help you take the next step.
Ready to start your GLP-1 weight-loss program in Greater St. Louis?
Check eligibility in about 2 to 5 minutes. If eligible, complete the secure intake for clinical review. Praxiom aims to review completed intakes and follow up within one business day when possible.
Check EligibilityNo payment required. Confidential. Eligibility check takes 2-5 minutes.
Praxiom Health, serving the Greater St. Louis area and 45 states plus Washington, D.C.
230 South Bemiston Suite 1000, St. Louis, MO 63105
1-888-455-3411 · hello@praxiomhealth.com
LegitScript Certified | HIPAA-compliant systems | Medically supervised GLP-1 care